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However, these patients often constitute an important subgroup of the disease population. By extending existing trial infrastructure, efforts to evaluate such patients in parallel cohort arms provided an efficient means of generating multicenter prospective data in patients for whom there were significant gaps in medical knowledge, laying the foundation for potential future trials involving these VTE subgroups of interest.

Since keeping a patient on anticoagulant medication involves a continuous tradeoff between the risk of bleeding related to anticoagulation and the risk of developing more blood clots each of which potentially can be life-threatening , Goldenberg and colleagues including University of Colorado-based biostatistician-leader John Kittelson, Ph.

The JAMA publication reports the findings of the randomized controlled trial involving over patients across 42 of the 51 centers that participated in the overall study , while the results of the parallel cohorts involving more than additional patients will be the subject of subsequent publications.

Goldenberg and his team are applying for NIH funding to follow up on how the Kids-DOTT findings are disseminated and adopted into practice globally, and to monitor the degree to which the favorable outcomes measured in Kids-DOTT continue to be observed in subsequent real-world experience.

The immediate legacy of Kids-DOTT will go beyond its practice-changing findings, as it signals that it is a very auspicious time to be a part of pediatric thrombosis. Michael Wilsey, M. Search for:. General News. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Federal Government. Read our disclaimer for details. Before participating in a study, talk to your health care provider and learn about the risks and potential benefits.

Learn more. Try the modernized ClinicalTrials. Learn more about the modernization effort. Learn about the different features of the search results list, including how to customize your display. Learn how to find studies that have been updated with study results, including studies with results that have been published in medical journals. Try the modernized ClinicalTrials. Learn more about the modernization effort. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

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